教師基本信息：
姓名：鄭琰
職稱：研究員
電子郵箱：yan_zheng@fudan.edu.cn
辦公地點：C601
研究方向：
從事肥胖和營養的分子流行病學研究，應用高通量多組學（尤其是代謝組和人體微生物組）技術發現疾病和飲食的生物標誌物，探索飲食與基因交互作用等。
個人簡介：
2005年獲首都醫科大學臨床醫學學士學位，2008年獲狗万外围充值 上海醫學院內科學碩士學位。2008-2010年就讀於美國Emory大學並獲公共衛生碩士學位，2010-2013年就讀於美國德州大學公共衛生學院並獲流行病學博士學位。2014-2017在美國哈佛大學陳曾熙公共衛生學院從事博士後研究。2017年加入万博英超狼队网官方网 ，任青年研究員、博士生導師、遺傳工程國家重點實驗室PI、狗万外围充值 附屬中山醫院雙聘教授，2021年12月聘為狗万外围充值 研究員。
擔任中國營養學會營養流行病分會/基礎營養學分會委員、Molecular Genetics and Genomics雜誌副主編等多個學術兼職職務。以重要作者身份在JAMA、BMJ、Nat Aging、Nat Microbiol、Natl Sci Rev等雜誌上發表文章，多篇入選ESI高被引論文，並受到國內外媒體報道。
授課情況：
1. 本科生全英文課程Bioethics；
2. 研究生必修課《科研倫理與規範》
招生專業：
遺傳學、生物信息學、生物學、生物醫藥
科研項目：
1. 國家科學技術部國家重點研發項目（2021-2026 年）課題主持
2. 狗万外围充值 義烏基地項目（2021-2023年）主持
3. 國家科學技術部國家重點研發項目（2019-2023 年）參與
4. 上海市東方學者計劃（人才項目）（2019-2012年）
5. 國家自然科學基金麵上基金項目（2019-2023年）主持
6. 國家自然科學基金應急基金項目（2018年）主持
7. 上海市浦江人才計劃（人才項目）（2018-2019年）
獲獎情況：
1. 入選“全球前2%頂尖科學家榜單”（2023，2024年）
2. 中國高被引學者（2022，2023，2024年）
3. 複星獎教金一等獎（2022年）
代表性論文和論著：
1. Shuchun Lin#, Zhonghan Sun#, Xinna Zhu#, Mengjing Wang, Qian Zhang, Jing Qian, Hui Zhang, Zhendong Mei, Yanni Pu, Mengmeng Kong, Peifeng Guo, Xiaofeng Zhou, Jin Li, Xuehui Sun, Liang Ma, Xueli Zhang, Fangqing Zhao, Jing Nie, Shangyu Hong, Jing Chen*, Xiaofeng Wang*, Xiao Li*, Yan Zheng*. Gut microbial ammonia metabolism contributes to the pathogenesis of chronic kidney disease. Nature Microbiology.2025 (Accepted)
2. Chenhao Lin#, Mingfeng Xia#, Yuxiang Dai#, Qingxia Huang#, Zhonghan Sun, Guoqing Zhang, Ruijin Luo, Qianqian Peng, Jinxi Li, Xiaofeng Wang, Huandong Lin, Xin Gao, Huiru Tang, Xia Shen, Sijia Wang, Li Jin*, Xingjie Hao*, Yan Zheng*. Cross-ancestry analysis of Chinese and European populations reveals novel insights into the genetic architecture and disease implications of metabolites. Cell Genomics.2025 Apr 9;5(4):100810.
3. Zhonghan Sun, Yan Zheng. Metabolic diseases in the East Asian populations. Nature Reviews Gastroenterology & Hepatology. 2025. (Online Published)
4. Xiao Li#, Jie Yang#, Xiaofeng Zhou#, Chen Dai, Mengmeng Kong, Linshan Xie, Chenglin Liu, Yilian Liu, Dandan Li, Xiaonan Ma, Yuxiang Dai, Yan Sun, Zhijie Jian, Xiaohuan Guo, Xu Lin, Yixue Li, Liang Sun, Xin Liu, Li Jin, Huiru Tang, Yan Zheng*, and Shangyu Hong*. Ketogenic diet-induced bile acids protect against obesity through increased calorie excretion. Nature Metabolism. 2024 Jul;6(7):1397-1414.
5. Pu Y#, Sun Z#, Zhang H#, Huang Q#, Wang Z, Mei Z, Wang P, Kong M, Yang W, Lin C, Zhou X, Lin S, Huang Q, Huang L, Sun L, Yuan C, Tang H*, Wang X*，Zheng Y*. Gut microbial features and circulating metabolomic signatures of frailty in older adults. Nature Aging. 2024 Sep;4(9):1249-1262.
6. Senying Lai, Yan Yan, Yanni Pu,Shuchun Lin, Jian-Ge Qiu,Bing-Hua Jiang, Marisa Isabell Keller, Mingyu Wang, Peer Bork*, Wei-Hua Chen*, Yan Zheng*. Xing-Ming Zhao*, Enterotypes of the human gut mycobiome. Microbiome. 2023 Aug 11;11(1):179
7. Yuxiang Dai, Zhonghan Sun, Yan Zheng*, Junbo Ge*. Recent advances in the gut microbiome and microbial metabolites alterations of coronary artery disease. Science Bulletin.2023 Mar 30;68(6):549-552.
8. Zhonghan Sun#, Xiong-Fei Pan#, Xiao Li, Limiao Jiang, Ping Hu, Yi Wang, Yi Ye, Ping Wu, Bin Zhao, Jianguo Xu, Mengmeng Kong, Yanni Pu, Manying Zhao, Jianying Hu, Jinfeng Wang, Guo-Chong Chen, Changzheng Yuan, Yongfu Yu, Xiang Gao, Fangqing Zhao, An Pan*, Yan Zheng*. The Gut Microbiome Dynamically Associates with Host Glucose Metabolism throughout Pregnancy: Longitudinal Findings from a Matched Case-control Study of Gestational Diabetes Mellitus. Advanced Science. 2023 Jan 22; e2205289.
9. Kang Yao, Yuxiang Dai, Juan Shen, Yi Wang, Huanjie Yang, Runda Wu, Qijun Liao, Hongyi Wu, Xiaodong Fang, Shalaimaiti Shali, Lili Xu, Meng Hao, Chenhao Lin, Zhonghan Sun, Yilian Liu, Mengxin Li, Zhen Wang, Qiang Gao, Shuning Zhang, Chenguang Li, Wei Gao, Lei Ge, Yunzeng Zou, Aijun Sun, Juying Qian, Li Jin, Shangyu Hong*, Yan Zheng*, Junbo Ge*. Exome sequencing identifies rare mutations of LDLR and QTRT1 conferring risk for early-onset coronary artery disease in Chinese. National Science Review. 2022 May 31;9(8): nwac102.
10. Yan Zheng, Yanping Li, Ambika Satija, An Pan, Mercedes Sotos-Prieto, Eric Rimm, Walter C. Willett, and Frank B. Hu. Association of Changes in Red Meat Consumption with Total and Cause-Specific Mortality among U.S. Women and Men: Two Large Prospective Cohort Studies. The BMJ. 2019 June 12; doi:10.1136/bmj. I2110.
11. Yan Zheng, Sylvia H Ley, Frank B Hu. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018 Feb;14(2):88-98. Selected in 100 most influential international academic papers in China, 2018.
12. Yan Zheng, JoAnn E. Manson, Changzheng Yuan, Matthew H. Liang, Francine Grodstein, Meir J. Stampfer, Walter C. Willett, and Frank B. Hu. Associations of weight gain from early to middle adulthood with major health outcomes in later life. Journal of the American Medical Association (JAMA). 2017;318(3):255-269.