洪尚宇

發布時間：2021-06-27瀏覽次數：5237

教師基本信息：

姓名：洪尚宇（Shangyu Hong）

職稱：研究員（Principal Investigator）

電子郵箱：shangyu_hong@fudan.edu.cn

辦公地點：狗万外围充值 江灣校區生科院樓D215（Room D215, School of Life Science, Fudan Univeristy）

辦公電話：021-31246658


研究方向：

1、研究飲食與營養代謝相關基因的交互作用；

2、研究肝髒和脂肪組織糖脂代謝穩態與代謝性疾病發病機製。

1. The function of critical genes related to nutrients metabolism;

2. The balance of sugar-lipid metabolism and related metabolic diseases.


個人簡介：

2001年本科畢業於武漢大學生科院，2007年博士畢業於中科院上海生科院生化細胞所，畢業後於哈佛大學醫學院進行博士後研究和工作，2017年進入狗万外围充值 生科院任教。主持多項國家級科研項目。獲2018年上海市“浦江人才”，2020年湖北省科技進步三等獎。

In 2001, B.S. from Wuhan University. In 2007, Ph.D. from Shanghai Institute of Biochemistry and Cell Biology. Postdoctoral training in Harvard Medical School. Since 2017, Principal Investigator in Fudan University. In 2018, recruited in “Pujiang Talent Program”. In 2020, awarded the third prize of scientific and technological progress in Hubei Province.


授課情況：

《生物化學》、《科研倫理與規範》

《Biochemistry》、《Bioethics》。


招生專業：生理學與神經生物學係（Physiology and Neurobiology）


科研項目：

  1. 國家自然科學基金委麵上項目“腸道菌群在生酮飲食糖脂代謝中的調控作用與分子機製”，2023.01-2026.12，負責人；

  2. 上海市自然科學基金麵上項目“生酮飲食通過腸道菌群及特異性膽汁酸改變宿主代謝”，2023.04-2026.03，項目負責人；

  3. 國家科技部重點研發計劃“發育編程及其代謝調控”重點專項項目“分泌蛋白對能量穩態的調控和機製”， 2022.01-2026.12，項目骨幹；

  4. 國家科技部重點研發計劃“發育編程及其代謝調控”重點專項項目“不同發育階段腸道菌群特征及其對發育的影響”， 2020.01-2024.12，項目骨幹；

  5. 國家自然科學基金委麵上項目“煙酰胺N-甲基轉移酶（Nnmt）在肝髒代謝中的功能和分子機製研究”，2020.01-2023.12，項目負責人；

  6. 國家自然科學基金委重大研究計劃-培育項目“Vgll4在糖脂代謝調控中的功能和分子機製研究”，2020.01-2022.12，項目負責人；

  7. 上海市“浦江人才”項目“煙酰胺N-甲基轉移酶（Nnmt）在甲硫氨酸循環中的功能與機製研究”，2018.07-2020.06，項目負責人；


代表性論文和論著：

  1. Yilian Liu*, Wanglei Zhong*, Xiao Li*, Feng Shen*, Xiaonan Ma, Qi Yang, Shangyu Hong#, Yan Sun#. Diets, Gut Microbiota and Metabolites. Phenomics2023 Mar 2;3(3):268-284.

  2. Kang Yao*, Yuxiang Dai*, Juan Shen*, Yi Wang*, Huanjie Yang, Runda Wu,Qijun Liao, Hongyi Wu, Xiaodong Fang, Shalaimaiti Shali, Lili Xu, Meng Hao, Chenhao Lin, Zhonghan Sun, Yilian Liu, MengxinLi, Zhen Wang, Qiang Gao, Shuning Zhang, Chenguang Li, Wei Gao, Lei Ge, Yunzeng Zou, Aijun Sun, Juying Qian, Li Jin, Shangyu Hong#, Yan Zheng#, and Junbo Ge#. Exome sequencing identifies rare mutations of LDLR and QTRT1 conferring risk for early-onset coronary artery disease in Chinese. Natl Sci Rev 2022 May 31;9(8).

  3. Chuanyou Yi*, Dandan Li*, Xiao Guo*, Jinhui Wang, Cenxi Liu, Guangxing Lu, He Huang#, Shangyu Hong#, Jin Li#. The storage conditions of high fat diet are the key factors for diet induced obesity and liver damage. Nutrients.2022May 26; 14(11), 2222.

  4. Dandan Li*, Chuanyou Yi*, He Huang, Jin Li# and Shangyu Hong#. Hepatocyte specific depletion of Nnmt protects the mice from non-alcoholic steatohepatitis. J Hepatol. 2022 Mar 30;S0168-8278(22)00191-X.

  5. Zhuang Wei, Jigang Lei, Feng Shen, Yuxiang Dai, Yan Sun, Yilian Liu, Yan Dai, Shilong Wang, Zhengjun Chen#, Kan Liao# and Shangyu Hong#.Cavin1 deficiency causes disorder of hepatic glycogen metabolism and neonatal death by impacting fenestrations in liver sinusoidal endothelial cells. Adv. Sci. 2020 Aug 21;7(19):2000963.

  6. Shanshan Guo, Yiru Huang, Yan Zhang, He Huang, Shangyu Hong# and Tiemin Liu#. Impacts of exercise interventions on different diseases and organ functions in mice. J. Sport Health Sci. 2020 Jan; 9(1): 53-73.

  7. Shangyu Hong#, Bo Zhai, Pavlos Pissios#. Nicotinamide N-Methyltransferase Interacts with Enzymes of the Methionine Cycle and Regulates Methyl Donor Metabolism. Biochemistry. 2018 Oct 9;57(40):5775-5779.

  8. Shangyu Hong, Wei Song, Peter-James H. Zushin, Bingyang Liu, Mark P. Jedrychowski, Amir I. Mina, Zhaoming Deng , Dimitrije Cabarkapa, Jessica A. Hall , Colin J. Palmer, Hassan Aliakbarian,John Szpyt, Steven P. Gygi, Ali Tavakkoli, Lydia Lynch, Norbert Perrimon, Alexander S. Banks. Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes. Mol Metab.2018 Jun;12:25-38.

  9. Shangyu Hong, Jose M Moreno-Navarrete, Xiaojing Wei, Yusuke Kikukawa, Iphigenia Tzameli, Deepthi Prasad, Yoonjin Lee, John M Asara, Jose Manuel Fernandez- Real, Eleftheria Maratos-Flier and Pavlos Pissios. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nat Med. 2015 Aug;21(8):887-94. Highlight in Cell Metab 2015 Aug 4;22(2):200-1.

  10. Alexander M. Real*, Shangyu Hong* and Pavlos Pissios. Nicotinamide N-Oxidation by CYP2E1 in Human Liver Microsomes. Drug Metab Dispos. 2013 41 (3), 550-553.

  11. Shangyu Hong, Hairong Huo, Jinfei Xu and Kan Liao. Insulin-Like Growth Factor-1 Receptor Signaling in 3T3-L1 Adipocyte Differentiation Requires Lipid Rafts But Not Caveolae. Cell Death Differ. 2004 Jul;11(7):714-23.



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