教師基本信息:
姓名:高煥慶
職稱:青年副研究員
電子郵箱:gao_hq@fudan.edu.cn
辦公地點:狗万外围充值 江灣校區生科院D205
研究方向:
主要研究方向是脂肪組織和肝髒的生理作用和慢性代謝性疾病包括肥胖、糖尿病、非酒精性脂肪肝的發病機製。
個人簡介:
重慶醫科大學與倫敦大學學院聯合培養博士,南方科技大學万博体育分 博士後,2020年6月作為研究助理教授/副研究員入職南方科技大學醫學院,2022年10月入職万博英超狼队网官方网 聘為青年副研究員。主要研究方向是脂肪組織和肝髒的生理作用和慢性代謝性疾病包括肥胖、糖尿病、非酒精性脂肪肝的發病機製。相關研究以第一作者/通訊作者(含共同)發表在Nature Communications(x2)、STTT、Diabetes、elife、JBC等主流期刊。先後主持國家自然科學基金麵上項目及省市級項目等。
代表性論文和論著:
1 Gao H* #, Zhong Y, Lin S, Yan Q, Zou X, Xiao G. Bone marrow adipoq+ cell population controls bone mass via sclerostin in mice. Signal Transduct Target Ther. 2023 Jul 10;8(1):265.(# 共同通訊)
2 Guo S, Feng Y, Zhu X, Zhang X, Wang H, Wang R, Zhang Q, Li Y, Ren Y, Gao X, Bian H, Liu T, Gao H#, Kong X#. Metabolic crosstalk between skeletal muscle cells and liver through IRF4-FSTL1 in nonalcoholic steatohepatitis. Nat Commun. 2023 Sep 28;14(1):6047. # 共同通訊)
3. Gao H, Zhou L, Zhong Y, Ding Z, Lin S, Hou X, Zhou X, Shao J, Yang F, Zou X, Cao H, Xiao G. Kindlin-2 haploinsufficiency protects against fatty liver by targeting Foxo1 in mice. Nat Commun. 2022 Feb 23;13(1):1025.
4. Gao H, Zhong Y, Ding Z, Lin S, Hou X, Tang W, Zhou X, Zou X, Shao J, Yang F, Bai X, Liu C, Cao H, Xiao G. Pinch Loss Ameliorates Obesity, Glucose Intolerance, and Fatty Liver by Modulating Adipocyte Apoptosis in Mice. Diabetes. 2021 Nov;70(11):2492-2505.
5. Gao H, Zhong Y, Zhou L, Lin S, Hou X, Ding Z, Li Y, Yao Q, Cao H, Zou X, Chen D, Bai X, Xiao G. Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function. elife. 2023 Jan 9;12:e81792.
6. Gao H, Guo Y, Yan Q, Yang W, Li R, Lin S, Bai X, Liu C, Chen D, Cao H, Xiao G. Lipoatrophy and metabolic disturbance in mice with adipose-specific deletion of kindlin-2. JCI Insight. 2019 Jul 11;4(13):e128405.
7. Tang W*, Ding Z*, Gao H*, Yan Q, Liu J, Han Y, Hou X, Liu Z, Chen L, Yang D, Ma G, Cao H. Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS/PPARγ/FABP4 signaling in mice. Acta Pharm Sin B. 2023 Nov;13(11):4535-4552. doi: 10.1016/j.apsb.2023.07.001.
8. Yan Q*, Gao H*, Yao Q, Ling K, Xiao G. Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling. J Biol Chem. 2022 Mar;298(3):101639.