鄭煜芳

發布者:王詩銘發布時間:2021-08-01瀏覽次數:653

教師基本信息

姓名:鄭煜芳

職稱:研究員

電子郵箱zhengyf@fudan.edu.cn

辦公地點:發育樓312

辦公電話021-312420608312

個人網頁/課題組主頁http://idm.fudan.edu.cn/zyf.htm


研究方向

胚胎發育異常導致的重大疾病的分子遺傳和發育機製


個人簡介

1993年進入清華大學生物科學與技術係,1997年獲學士學位,1999年獲理學碩士學位。19998月赴美國康奈爾大學醫學院生理、生物物理和分子醫學係,於2004年獲博士學位。同年獲美國耶魯大學的Endowed Postdoctoral Fellowship,從事博士後研究。2007年起獲聘為狗万外围充值 副教授,碩導。20138月兼職狗万外围充值 發育生物學研究所PI20163月起任狗万外围充值 附屬婦產科醫院生殖發育研究院副研究員PI201712月起任研究員。曾獲得上海市浦江人才計劃,狗万外围充值 卓學人才計劃等獎項。曾承擔的多項國家自然基金委項目和上海市科委項目;作為課題骨幹參與基金委重點項目、國家重點研發計劃、973計劃、863等多項重大項目。


授課情況

生物化學A(上):2008-2016

發育神經生物學(全英文):2009-2016

發育生物學:2019-至今


招生專業

遺傳學


代表性論文和論著

  1. Li C, Zheng Y, Zheng Y*, Xu Z*. SRPS Associated Protein WDR60 Regulates the Multipolar-to-Bipolar Transition of Migrating Neurons during Cortical Development. Cell Death & Dis. 2021 Jan 12;12(1):75. doi: 10.1038/s41419-020-03363-3.

  2. Yin H, Peng R, Chen Z, Wang H, Zhang T, Zheng Y*. WDR34 mutation from anencephaly patients impaired both SHH and PCP signaling pathways. Journal of Human Genetics, 2020 Nov; 65(11):985-993. doi: 10.1038/s10038-020-0793-z.

  3. Xu Y, Li X, Zhong Y, Zheng Y*. The evolution and diversity of axon guidance Robo receptor family genes. Journal of Systematics and Evolution, 2021, 59 (1): 169-182, DOI: 10.1111/jse.12587,

  4. Xie Y, Ma A, Wang B, Peng R, Jing Y, Wang D, Finnell RH., Qiao B, Wang Y*, Wang H*, Zheng Y*. Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling. Clin Sci (Lond). 2019 Jan 22;133(2):225-238. doi: 10.1042/CS20180842.

  5. Wang Y#, Zheng Y#,*, Yang S, Yang Z, Zhang L, He Y, Gong X, Liu D, Finnell R.H., Qiu Z, Du Y*, Wang H*. MicroRNA-197 controls ADAM10 expression to mediate MeCP2’s role in the differentiation of neuronal progenitors. Cell Death & Differ 2019 Oct;26(10):1863-1879. DOI: 10.1038/s41418-018-0257-6

  6. Chen Z#, Lei Y#, Zheng Y#, Aguiar-Pulido V, Ross M.E., Peng R, Jin L, Zhang T*, Finnell R.H.*, Wang H*. Threshold for neural tube defect risk by accumulated singleton loss-of-function variants. Cell Res. 2018 Oct;28(10):1039-1041. doi: 10.1038/s41422-018-0061-3.

  7. Wang B, Zhang Y, Dong H, Gong S, Wei B, Luo M, Wang H, Wu X, Liu W, Xu X*, Zheng Y*, Miao Sun*. Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice. Cell Death & Dis. 2018 May 1; 9(520). doi: 10.1038/s41419-018-0563-4

  8. Gao X, Finnell R, Wang H, Zheng Y*. Network correlation analysis revealed potential new mechanisms for neural tube defects beyond folic acid. Birth Defects Res 2018 Jul 17;110(12):982-993. doi: 10.1002/bdr2.1336.

  9. Shi Z, Yang X, Li B, Chen S, Yang L, Chen L, Zhang T, Wang H, Zheng Y*. Novel mutation of LRP6 identified in Chinese Han population links canonical WNT signaling to neural tube defects. Birth Defects Res2018 Jan 15;110(1):63-71. doi: 10.1002/bdr2.1122.

  10. Wang B#, Zheng Y#, Shi H, Du X, Zhang Y, Wei B, Luo M, Wang H, Wu X, Hua X, Sun M*, Xu X*. Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice.Genes Brain Behav. 2017 Feb;16(2):296-307.

  11. Qiao X#, Liu Y#, Li P, Chen Z, Li H, Yang X, Finnell RH, Yang Z, Zhang T, Qiao B, Zheng Y*, Wang H*. Genetic analysis of rare coding mutations of CELSR1-3 in congenital heart and neural tube defects in Chinese people. Clin Sci (Lond). 2016 Dec 1; 130(24): 2329-40.

  12. Liu B, Ma A, Zhang F, Wang Y, Li Z, Li Q, Xu Z, Zheng Y*.MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis.Scientific reports 2016 Feb 12;6:21534. doi: 10.1038/srep21534.


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