教師基本信息：
姓名：馮喆
職務：青年研究員，博師生導師
電子郵箱：zhefeng@fudan.edu.cn
辦公地點：万博英超狼队网官方网 A407室
信息板塊：
主要研究方向
中心體的組裝與調控機製；
中心體功能障礙對於癌症、發育類等疾病的致病機理；
相分離介導的無膜細胞器組裝和調控的功能機理。
個人簡介
2011年獲英國帝國理工大學學士學位，2016年獲英國牛津大學病理學博士學位（Prof. Jordan Raff實驗組，碩博連讀）。此後在同實驗室從事博士後研究。2017年入職香港科技大學，擔任研究助理教授（張明傑院士實驗室組），獲選港科大高研院青年學人榮譽，領導主持香港研究資助局優配研究金項目。2021年獲得國家和上海人才計劃支持，人才引進狗万外围充值 生命科學院。
招生專業
細胞與發育生物學、生物化學、結構生物學、遺傳學
代表性論文和論著
1. Feng, Z., Jia, B., Tao, J. and Zhang, M. (2021) “IRSp53 promotes postsynaptic density formation and actin filament bundling via phase separation”. Journal of Cell Biology, under revision.
2. Feng, Z.*, Caballe, A.*, Wainman, A.*, Johnson, S.*, Haensele, A.F.M., Cottee, M.A., Conduit, P.T., Lea, S.M., and Raff, J.W. (2017) “Structural basis for mitotic centrosome assembly in flies”. Cell169, 1078-1089. (Highlighted in Faculty 1000)
3. Conduit, P.T.*, Feng, Z.*(Equal contribution), Richens, J.H., Baumbach, J., Wainman, A., Bakshi, S., Dobbelaere, J., Johnson, S., Lea, S.M., and Raff, J.W. (2014) “The centrosome-specific phosphorylation of Cnn by Polo/Plk1 drives Cnn scaffold assembly and centrosome maturation”. Developmental Cell 28, 659-669. (Highlighted in Faculty 1000)
4. Feng, Z., Jia, B., and Zhang, M. (2021) “Liquid-liquid phase separation in biology: specific stoichiometric molecular interactions vs promiscuous interactions mediated by disordered sequences”. Biochemistry 60, 2397-2406.
5. Wu, X., Cai, Q., Feng, Z., and Zhang, M. (2020) “Liquid-liquid phase separation in neuronal development and synaptic signaling”. Developmental Cell 55, 18-29.
6. Feng, Z.,Chen, X., Wu, X., and Zhang, M. (2019) “Formation of biological condensates via phase separation: Characteristics, analytical methods, and physiological implications”. Journal of Biological Chemistry294, 14823-14835.
7. Li, Z., Liu, H., Li, J., Yang, Q., Feng, Z., Li, Y., Yang, H., Yu, C., Wan, J., Liu, W., and Zhang, M. (2019) “Homer tetramer promotes actin bundling activity of Drebrin”. Structure27, 27-38.
8. Feng, Z., Chen, X., Zeng, M., and Zhang, M. (2018) “Phase separation as a mechanism for assembling dynamic postsynaptic density signaling complexes”. Current Opinion in Neurobiology 57, 1-8.
9. Feng, Z., Zeng, M., Chen, X., and Zhang, M. (2018) “Neuronal synapses: microscale signal processing machineries formed by phase separation?”. Biochemistry 57, 2530-2539.
Zhe Feng
Position：Young Investigator (Tenure track)
Email：zhefeng@fudan.edu.cn
Address：Room A407, Institute of Life Science, Fudan University
Major research directions:
Structural and functional basis underlying centrosome assembly and organization.
How is centrosome dysfunction linked to cancer and developmental diseases?
Phase separation-mediated membraneless organelle formation and regulation.
Education and research background:
Zhe Feng received her bachelor’s degree in Biochemistry at Imperial College London in 2011. She was a PhD student with Prof. Jordan Raff at University of Oxford, where she performed structural and functional characterization of major scaffold proteins in centrosomes. She then worked as a Research Assistant Professor/IAS junior fellow with Prof. Mingjie Zhang at HKUST, focused on phase separation-driven non-membrane bound organelle assembly and regulation. She joins the Institute of Life Science, Fudan in 2021.
Admissions Major
Developmental and Cell Biology, Biochemistry, Structural Biology, Genetics.
Selected Publications
1. Feng, Z., Jia, B., Tao, J. and Zhang, M. (2021) “IRSp53 promotes postsynaptic density formation and actin filament bundling via phase separation”. Journal of Cell Biology, under revision.
2. Feng, Z.*, Caballe, A.*, Wainman, A.*, Johnson, S.*, Haensele, A.F.M., Cottee, M.A., Conduit, P.T., Lea, S.M., and Raff, J.W. (2017) “Structural basis for mitotic centrosome assembly in flies”. Cell169, 1078-1089. (Highlighted in Faculty 1000)
3. Conduit, P.T.*, Feng, Z.*(Equal contribution), Richens, J.H., Baumbach, J., Wainman, A., Bakshi, S., Dobbelaere, J., Johnson, S., Lea, S.M., and Raff, J.W. (2014) “The centrosome-specific phosphorylation of Cnn by Polo/Plk1 drives Cnn scaffold assembly and centrosome maturation”. Developmental Cell 28, 659-669. (Highlighted in Faculty 1000)
4. Feng, Z., Jia, B., and Zhang, M. (2021) “Liquid-liquid phase separation in biology: specific stoichiometric molecular interactions vs promiscuous interactions mediated by disordered sequences”. Biochemistry 60, 2397-2406.
5. Wu, X., Cai, Q., Feng, Z., and Zhang, M. (2020) “Liquid-liquid phase separation in neuronal development and synaptic signaling”. Developmental Cell 55, 18-29.
6. Feng, Z.,Chen, X., Wu, X., and Zhang, M. (2019) “Formation of biological condensates via phase separation: Characteristics, analytical methods, and physiological implications”. Journal of Biological Chemistry294, 14823-14835.
7. Li, Z., Liu, H., Li, J., Yang, Q., Feng, Z., Li, Y., Yang, H., Yu, C., Wan, J., Liu, W., and Zhang, M. (2019) “Homer tetramer promotes actin bundling activity of Drebrin”. Structure27, 27-38.
8. Feng, Z., Chen, X., Zeng, M., and Zhang, M. (2018) “Phase separation as a mechanism for assembling dynamic postsynaptic density signaling complexes”. Current Opinion in Neurobiology 57, 1-8.
9. Feng, Z., Zeng, M., Chen, X., and Zhang, M. (2018) “Neuronal synapses: microscale signal processing machineries formed by phase separation?”. Biochemistry 57, 2530-2539.