教師基本信息
職稱:教授
電子郵箱:huiru_tang@fudan.edu.cn
辦公地點:複旦生科院D105
辦公電話:021-31246725
個人簡介
男,1966年生,國家傑出青年科學基金獲得者、英國皇家化學會會士、狗万外围充值 特聘教授、國家重點研發計劃項目首席。1986年獲西北輕工業學院(現陝西科技大學)學士學位,1994年獲倫敦大學博士學位。1992-2000年英國BBSRC食品研究所Research Scientist、Senior Scientist。2001-05年英國帝國理工學院生物醫學部Senior Scientist。2005-14年中科院武漢物數所研究員、博士生導師、研究部副主任、中科院生物磁共振分析重點實驗室創建主任。2014年加盟万博英超狼队网官方网 。曾任英國NHS、科技部973及蛋白質重大計劃等評審專家、J Proteome Res編委。在Nature及PNAS等上發表SCI論文200餘篇,被引1萬餘次(h指數~58)。獲批發明專利5項。部分工作被Science、Nature等作為“研究亮點”專文評述。現任中國生物物理學會理事、代謝組學分會會長、自由基生物學及醫學分會常務理事、生物磁共振專委會委員,中國抗癌協會腫瘤代謝專業委員會常務理事,中國營養學會基礎營養學分會理事,Metabolomics、Curr Metabolomics、Arch Pharm和《基礎醫學與臨床》等編委,Nutrition & Metabolism及Phenomics等副主編。
Personal website: http://www.metabolome.cn/
研究方向
研究代謝物結構與功能30餘年,正發展高通量超靈敏代謝組學技術、代謝組與轉錄組/蛋白質組/微生物組等數據整合技術,研究肥胖等重大疾病發生發展的代謝組基礎。曾主持完成國家傑出青年科學基金、國家重點研發計劃、國家自然科學基金重大項目、肥胖等973項目課題多項。現承擔國家創新群體、市級重大專項等課題。
獲獎情況
英國皇家化學會會士(2005)、國家傑出青年科學基金(2008)、“新世紀百千萬人才工程”國家級人選稱號(2009)、王天眷波譜學獎(2010)、武漢市優秀科技工作者(2011)。
代表性論文和論著
* M. Xia, et al, “Insights into contribution of genetic variants towards the susceptibility of MAFLD revealed by the NMR_based lipoprotein profiling”, J Hepatol, 74:974-977, 2021. 【IF~25.1】
* Y. Xu, et al, “Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues”, EMBO J. e108069, 2021. 【IF~11.6】
* M. Wang, et al, “Glucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pH”, Cell Rep, 35:108992, 2021. 【IF~9.4】
* Q. Hu, et al, “Quantitative structure-retention relationship for reliable metabolite identification and quantification in metabolomics using IPRP-LC-MS/MS”, Talanta, 238:123059, 2022.【IF~6.1】
* R. Loo, et al, “A feasibility study of metabolic phenotyping of dried blood spot specimens in rural Chinese women exposed to household air pollution”,J Expo Sci Environ Epidemiol, 31:328-344, 2021. 【IF~5.6】
* Z. Zhang, et al, “New types of ATP-grasp ligase are associated with the novel pathway for complicated mycosporine-like amino acid production in desiccation-tolerant cyanobacteria”, Environ Microbiol, 23:6420–6432. 2021.【IF~5.5】
* Y. An, et al, “Development and validation of an improved probabilistic quotient normalization method for LC/MS- and NMR-based metabonomic analysis”, Chin Chem Lett, 31:1827-1830, 2020. 【IF~6.8】
* J. Xue, et al, “A vitamin-C-derived DNA modification catalysed by an algal TET homologue”, Nature, 569:581–585, 2019【IF~50.0】
* H. Lin, et al, “Alterations of bile acids and gut microbiota in obesity induced by high fat diet in rat model”, J Agric Food Chem, 67:3624-3632. 2019.【IF~5.3, 高被引,年均17次】
* J. Gou, et al, “Discovery of a non-stereoselective cytochrome P450 catalyzing either 8α- or 8β-hydroxylation of germacrene A acid from the Chinese medicinal plant, Inula hupehensis”, Plant J,93:92-106, 2018.【IF~6.4】
* F. Chen, et al, “Combined metabonomic and quantitative RT-PCR analyses revealed metabolic reprogramming associated with Fusarium graminearum resistance in transgenic Arabidopsis thaliana”,Front Plant Sci, 8:2177, 2018.【IF~5.8】
* L. Zhang, et al, “Metabolomics reveals that dietary ferulic acid and quercetin modulate metabolic homeostasis in rats”, J Agric Food Chem, 66: 1723−1731, 2018. 【IF~5.3】
* C. Liu, B. Du, F. Hao, H. Lei, Q. Wan, G. He, Y. Wang. H. Tang, "Dynamic metabolic responses of brown planthoppers towards susceptible and resistant rice plants", PBJ, 15:1346, 2017.【IF~9.8】
* Q. Wan, et al, "Quantitative 13C traces of glucose fate in hepatitis B virus infected hepatocytes", Anal Chem, 89:3293–3299, 2017 【IF~7.0】
* Y. Kumar, et al, "Fusarium oxysporum mediates systems metabolic reprogramming of chickpea roots as revealed by a combination of proteomics and metabolomics", PBJ,14:1589, 2016【IF~9.8】
* H. Li, et al, "Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer", Cell Discov, 2:16031, 2016. 【IF~5.8】
* L. Sun, et al, "cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions". Cell Res, 25:429–444, 2015. 【IF~25.6】
* C. Zhang, et al, "Dietary modulation of gut microbiota contributes to alleviation of both genetic and simple obesity in children",eBioMedicine, 2:968-984, 2015. 【IF~8.1】
* L. Zhang, et al, “Selective metabolic effects of gold nanorods on normal and cancer cells and their application in anticancer drug screening”, Biomaterials, 34:7117-7126, 2013. 【IF~12.5】
* M. Li, et al, “Human symbiotic gut microbes specifically modulate metabolic phenotypes”, PNAS, 105:2117-2122, 2008. 【IF~11.2】
論文及引用Full Publication List
https://publons.com/researcher/2776607/huiru-tang/