周兆才

發布者：王詩銘發布時間：2021-05-06瀏覽次數：2607

教師基本信息

姓名：周兆才

職稱：教授

職務：院長助理

電子郵箱：zhouzhaocai@fudan.edu.cn

辦公地點：万博体育分 A407室

辦公電話：021-31246635

個人網頁/課題組主頁：//www.xahaidun.com/Data/View/3403


研究方向

腫瘤發生及免疫應答的分子細胞信號機製

本團隊主要以胃腸道為研究體係，闡釋組織器官生長與穩態維持的調控規律，揭示相關疾病的發生發展機製，發現診療標誌物，提出創新性的診療策略，獲得靶向藥物原型。未來將持續聚焦消化道腫瘤特別是胃癌，重點探究：（1）不同亞型胃癌的細胞起源與異質化演變，從而為研發新型靶向藥物提供理論基礎；（2）胃癌相關免疫微環境重塑與演化，從而為研發新型腫瘤免疫治療策略提供理論基礎。為此，我們將進一步交叉整合結構生物學、細胞信號轉導、小鼠模型、單細胞組學，以及類器官等技術體係，並著重發展以細胞-細胞互作為背景的遺傳譜係示蹤技術和以化學生物學為背景的多肽藥物設計及靶向幹預。


個人簡介

2004年博士畢業於中國科學技術大學，隨後赴美國賓州大學（UPenn）從事博士後研究。2009年引進回國，曆任中科院上海生化與細胞所、分子生物學國家重點實驗室、細胞生物學國家重點實驗室研究員。2014年被授予中科院傑出青年科技創新人才稱號。2017年任中科院分子細胞科學卓越創新中心特聘研究員，同年獲國家自然科學基金委醫學部“傑青”資助。2020年任狗万外围充值 特聘教授，遺傳工程國家重點實驗室研究組長。擔任國家科技部 “發育和代謝：組織器官生長與尺寸控製” 重點專項首席科學家。主持國家自然科學基金委重點、重大、麵上及上海市重點等基金項目，並獲中科院戰略性科技先導專項資助。曾任中科院與高校聯合交叉創新團隊負責人（GPCR信號轉導）。擔任Frontiers in Immunology等學術期刊編輯；《細胞生物學》、《生命的化學》等期刊編委；上海市生物工程學會理事、中國抗癌協會腫瘤胃腸病學專業委員會委員、中國細胞生物學會醫學細胞生物學分會委員。研究成果：

長期關注組織器官間通訊與疾病，近年來研究胃腸道腫瘤發生及免疫應答，代表性工作聚焦Hippo等器官尺寸控製信號通路調控胃腸道腫瘤發生及免疫應答的機製與功能，發現了一批疾病診斷標誌物和先導藥物，在Cancer Cell (2)、Nature Immunology、Nature Communications、Advanced Science、Nano Letters、Journal of Experimental Medicine (2)、EMBO Journal (2)、Cell Research (2)、Proceedings of National Academy of Sciences、Cancer Research、Protein Cell等國際學術期刊發表研究論文70餘篇，參與編寫英文專著1部，申請發明專利10餘項。成果被Cell、Nature Reviews Cancer、Cancer Cell、Nature China、Science Signaling、F1000Prime評價和推薦，多次應邀為Oncogene、Cellular Molecular Immunology等學術期刊撰寫綜述，為國際學術會議做大會報告，為Nature Cell Biology、Journal of Experimental Medicine、Nano Letters、Cell Research等期刊審稿。


授課情況


招生專業

遺傳學，細胞生物學,生物化學，發育生物學，生物醫學


代表性論文和論著

  1. Meng Y, Zhao Q, An L, Jiao S, Li R, Sang Y, Liao J, Nie P, Wen F, Ju J et al. A TNFR2-hnRNPK axis promotes primary liver cancer development via activation of YAP signaling in hepatic progenitor cells. Cancer Res 2021, 33619115.

  2. Tang Y, Fang G, Guo F, Zhang H, Chen X, An L, Chen M, Zhou L, Wang W, Ye T et al. Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer. Cancer Cell 2020, 38(1): 115-128 e119.

  3. An L, Nie P, Chen M, Tang Y, Zhang, H, Guan J, Cao Z, Hou C, Wang W, Zhao Y et al. MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway. The Journal of experimental medicine 2020, 217(6): e20191817.

  4. Xu J, Tang Y, Sheng X, Tian Y, Deng M, Du S, Lv C, Li G, Pan Y, Song Y et al: Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling. The EMBO journal 2020, 39(7):e103255.

  5. Tang Y, Chen M, Zhou L, Ma J, Li Y, Zhang H, Shi Z, Xu Q, Zhang X, Gao Z et al: Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling. Cell Discov 2019, 5:3.

  6. Li Y, Guan J, Wang W, Hou C, Zhou L, Ma J, Cheng Y, Jiao S, Zhou Z: TRAF3-interacting JNK-activating modulator promotes inflammation by stimulating translocation of Toll-like receptor 4 to lipid rafts. The Journal of biological chemistry 2019, 294(8):2744-2756.

  7. Jiao S, Guan J, Chen M, Wang W, Li C, Wang Y, Cheng Y, Zhou Z: Targeting IRF3 as a YAP agonist therapy against gastric cancer. The Journal of experimental medicine 2018, 215(2):699-718.

  8. Chen M, Zhang H, Shi Z, Li Y, Zhang X, Gao Z, Zhou L, Ma J, Xu Q, Guan J et al: The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer. The Journal of biological chemistry 2018, 293(37):14455-14469.

  9. Shi Z, He F, Chen M, Hua L, Wang W, Jiao S, Zhou Z: DNA-binding mechanism of the Hippo pathway transcription factor TEAD4. Oncogene 2017, 36(30):4362-4369.

  10. Jiao S, Li C, Hao Q, Miao H, Zhang L, Li L, Zhou Z: VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer. Nat Commun 2017, 8:14058.

  11. Zhang Z, Wang Y, Li C, Shi Z, Hao Q, Wang W, Song X, Zhao Y, Jiao S, Zhou Z: The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-kappaB Signaling via Partial Degradation of the NF-kappaB Subunit p100. The Journal of biological chemistry 2015, 290(32):19558-19568.

  12. Shi Z, Zhang Z, Zhang Z, Wang Y, Li C, Wang X, He F, Sun L, Jiao S, Shi W et al: Structural Insights into Mitochondrial Antiviral Signaling Protein (MAVS)-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Signaling. The Journal of biological chemistry 2015, 290(44):26811-26820.

  13. Shi Z, Jiao S, Zhou Z: Structural dissection of Hippo signaling. Acta biochimica et biophysica Sinica 2015, 47(1):29-38.

  14. Jiao S, Zhang Z, Li C, Huang M, Shi Z, Wang Y, Song X, Liu H, Li C, Chen M et al: The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6. Nature immunology 2015, 16(3):246-257.

  15. Hao Q, Jiao S, Shi Z, Li C, Meng X, Zhang Z, Wang Y, Song X, Wang W, Zhang R et al: A non-canonical role of the p97 complex in RIG-I antiviral signaling. The EMBO journal 2015, 34(23):2903-2920.

  16. Zhang W, Gao Y, Li P, Shi Z, Guo T, Li F, Han X, Feng Y, Zheng C, Wang Z et al: VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex. Cell research 2014, 24(3):331-343.

  17. Liu G, Shi Z, Jiao S, Zhang Z, Wang W, Chen C, Hao Q, Zhang M, Feng M, Xu L et al: Structure of MST2 SARAH domain provides insights into its interaction with RAPL. Journal of structural biology 2014, 185(3):366-374.

  18. Li C, Feng M, Shi Z, Hao Q, Song X, Wang W, Zhao Y, Jiao S, Zhou Z: Structural and Biochemical Insights into the Activation Mechanisms of Germinal Center Kinase OSR1. The Journal of biological chemistry 2014, 289(52):35969-35978.

  19. Jiao S, Wang H, Shi Z, Dong A, Zhang W, Song X, He F, Wang Y, Zhang Z, Wang W et al: A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer. Cancer cell 2014, 25(2):166-180.

  20. Chen CC, Shi ZB, Zhang WQ, Chen M, He F, Zhang ZZ, Wang YC, Feng M, Wang WJ, Zhao Y et al: Striatins Contain a Noncanonical Coiled Coil That Binds Protein Phosphatase 2A A Subunit to Form a 2: 2 Heterotetrameric Core of Striatin- interacting Phosphatase and Kinase ( STRIPAK) Complex*. Journal of Biological Chemistry 2014, 289(14):9651-9661.

  21. Zhang M, Dong L, Shi Z, Jiao S, Zhang Z, Zhang W, Liu G, Chen C, Feng M, Hao Q et al: Structural mechanism of CCM3 heterodimerization with GCKIII kinases. Structure (London, England : 1993) 2013, 21(4):680-688.

  22. Shi Z, Jiao S, Zhang Z, Ma M, Zhang Z, Chen C, Wang K, Wang H, Wang W, Zhang L et al: Structure of the MST4 in complex with MO25 provides insights into its activation mechanism. Structure (London, England : 1993) 2013, 21(3):449-461.

  23. Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z: Structural insights into SUN-KASH complexes across the nuclear envelope. Cell research 2012, 22(10):1440-1452.

  24. Song X, Li B, Xiao Y, Chen C, Wang Q, Liu Y, Berezov A, Xu C, Gao Y, Li Z et al: Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function. Cell reports 2012, 1(6):665-675.


Baidu
map