帝國理工學院醫學部外科學與腫瘤係教授
狗万外围充值 名譽教授
Jeremy Kirk Nicholson （傑裏米·柯克·尼科爾森）教授,男，1956年出生，博士，教授。1977年畢業於英國利物浦大學海洋生物學專業，獲學士學位；1980年獲倫敦大學省托馬斯醫院生物化學博士學位。1980-1981年在倫敦大學伯貝克學院化學係從事博士後研究，後升任講師；1992-1998年任伯貝克學院化學係生物化學教授；1998年起到帝國理工學院醫學部工作，曆任生物化學係主任（1998-2007）、生物分子醫學係主任（2007-2009），現為帝國理工學院醫學部外科學與腫瘤係教授。2016年11月任万博英超狼队网官方网 名譽教授。
Prof Jeremy Nicholson finished his Bachelor’s degree in marine biology at the University of Liverpool, UK in 1977 and obtained PhD in biochemistry at St Thomas’ Hospital Medical School, University of London in 1980. He was an RTZ post-doctoral research fellow during 1980-1981 at Department of Chemistry, Birkbeck College, University of London, where his career as Lecturer began and became Professor in Biological Chemistry in 1992. He joined Faculty of Medicine, Imperial College London as Professor of Biological Chemistry in 1998 and worked as Head of Biological Chemistry (1998-2007) and Head of Department of Biomolecular Medicine (2007-2009). He is currently Professor in Department of Surgery and Cancer, Faculty of Medicine, Imperial College London. He earned Honorary Professorship in the School of Life Sciences, Fudan University in November, 2016.
BSc Honours Marine Biology, University of Liverpool, UK (1977)
PhD, Biochemistry, St Thomas' Hospital Med School, University of London (1980)
RTZ Post-doctoral Research Fellow, Department of Chemistry, Birkbeck College, University of London (1980)
Lecturer in Chemistry, Dept. of Chemistry, Birkbeck College, University of London (1981)
Professor in Biological Chemistry, Dept of Chemistry, Birkbeck College, University of London (1992)
Head of Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College London (1998 – 2007)
Head of Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London (2007 – 2009)
Chair in Biological Chemistry, Head of Department of Surgery & Cancer, Faculty of Medicine, Imperial College London (2009 – )
在分子層麵上研究與代謝和醫學相關的物理、化學過程；利用波譜學和化學計量學手段，為人類疾病和毒理過程研究開發新型方法；基於代謝的自上而下的係統生物學及複雜係統衰竭的建模；代謝表型與係統醫學指導的個性化醫療；外科代謝組學，實時診斷及病患綜合建模；
Molecular physico-chemical processes in metabolism and medicine
Development of novel spectroscopic and chemometric tools for investigating human disease and toxicological mechanisms
Metabolism-driven top-down systems biology and modelling of complex system failure
Personalised healthcare through metabolic phenotyping and systems medicine
Surgical metabonomics, real-time diagnostics and integrative patient modeling
曾獲皇家化學會分析科學銀獎、分析化學統計與計量金獎、輝瑞全球化學領域獎等。
The Royal Society of Chemistry: 21st Silver Medal for Analytical Science (1992)
The Chromatographic Society: Jubilee Silver Medal (1994)
The Royal Society of Chemistry: 21st SAC Gold Medal for Analytical Chemistry (1997)
Pfizer Academic Innovation Award for Chemical and Medicinal Technology (2002)
The Royal Society of Chemistry: Silver Medal for Chemical Biology (2003)
Pfizer Global Chemistry Discipline Prize (2006)
The Royal Society of Chemistry Interdisciplinary Award (2008)
NIH: Stars in Cancer and Nutrition Distinguished Lecturer (2010)
Semmelweis - Budapest Prize (2010)
Robert Zhong Award in Surgery (Canada) (2013)
1. Nicholson, J. K.*, Kendall, M. D., Osborn, D.* 1983. Cadmium and Mercury Nephrotoxicity. Nature 304:633-635.
2. Brindle, J. T., Antti, H., Holmes, E., Tranter, G., Nicholson, J. K., Bethell, H. W. L., Clarke, S., Schofield, P. M., McKilligin, E., Mosedale, D. E., Grainger, D. J.* 2002. Rapid and Noninvasive Diagnosis of the Presence and Severity of Coronary Heart Disease Using 1H-NMR-Based Metabonomics. Nature Medicine 8:1439-1444.
3. Nicholson, J. K.*, Connelly, J., Lindon, J. C., Holmes, E. 2002. Metabonomics: A Platform for Studying Drug Toxicity and Gene Function. Nature Reviews Drug Discovery 1:153-161.
4. Nicholson, J. K.*, Wilson, I. D. 2003. Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism. Nature Reviews Drug Discovery 2:668-676.
5. Nicholson, J. K.*, Holmes, E., Lindon, J. C., Wilson, I. D. 2004. The Challenges of Modeling Mammalian Biocomplexity. Nature Biotechnology 22:1268-1274.
6. Wang, Y. L., Holmes, E., Nicholson, J. K., Cloarec, O., Chollet, J., Tanner, M., Singer, B. H., Utzinger, J*. 2004. Metabonomic Investigations in Mice Infected with Schistosoma Mansoni: An Approach for Biomarker Identification. Proc. Natl. Acad. Sci. USA 101:12676-12681.
7. Lindon, J. C.*, Nicholson, J. K., Holmes, E., Keun, H. C., Craig, A., Pearce, J. T. M., Bruce, S. J., Hardy, N., Sansone, S. A., Antti, H., Jonsson, P., Daykin, C., Navarange, M., Beger, R. D., Verheij, E. R., Amberg, A., Baunsgaard, D., Cantor, G. H., Lehman-McKeeman, L., Earll, M., Wold, S., Johansson, E., Haselden, J. N., Kramer, K., Thomas, C., Lindberg, J., Schuppe-Koistinen, I., Wilson, I. D., Reily, M. D., Robertson, D. G., Senn, H., Krotzky, A., Kochhar, S., Powell, J., van der Ouderaa, F., Plumb, R., Schaefer, H., Spraul, M. 2005. Summary Recommendations for Standardization and Reporting of Metabolic Analyses. Nature Biotechnology 23:833-838.
8. Nicholson, J. K.*, Holmes, E., Wilson, I. D. 2005. Gut Microorganisms, Mammalian Metabolism and Personalized Health Care. Nature Reviews Microbiology 3:431-438.
9. Clayton, T. A., Lindon, J. C., Cloarec, O., Antti, H., Charuel, C., Hanton, G., Provost, J. P., Le Net, J. L., Baker, D., Walley, R. J., Everett, J. R., Nicholson, J. K.* 2006. Pharmaco-Metabonomic Phenotyping and Personalized Drug Treatment. Nature 440:1073-1077.
10. Dumas, M. E.*, Barton, R. H., Toye, A., Cloarec, O., Blancher, C., Rothwell, A., Fearnside, J., Tatoud, R., Blanc, V., Lindon, J. C., Mitchell, S. C., Holmes, E., McCarthy, M. I., Scott, J., Gauguier, D., Nicholson, J. K.* 2006. Metabolic Profiling Reveals a Contribution of Gut Microbiota to Fatty Liver Phenotype in Insulin-Resistant Mice. Proc. Natl. Acad. Sci. USA 103:12511-12516.
11. Beckonert, O., Keun, H. C., Ebbels, T. M. D., Bundy, J. G., Holmes, E., Lindon, J. C., Nicholson, J. K.* 2007. Metabolic Profiling, Metabolomic and Metabonomic Procedures for NMR Spectroscopy of Urine, Plasma, Serum and Tissue Extracts. Nature Protocols 2:2692-2703.
12. Dumas, M. E., Wilder, S. P., Bihoreau, M. T., Barton, R. H., Fearnside, J. F., Argoud, K., D'Amato, L., Wallis, R. H., Blancher, C., Keun, H. C., Baunsgaard, D., Scott, J., Sidelmann, U. G., Nicholson, J. K.*, Gauguier, D.* 2007. Direct Quantitative Trait Locus Mapping of Mammalian Metabolic Phenotypes in Diabetic and Normoglycemic Rat Models. Nature Genetics 39:666-672.
13. Holmes, E., Loo, R. L., Stamler, J., Bictash, M., Yap, I. K. S., Chan, Q., Ebbels, T., De Iorio, M., Brown, I. J., Veselkov, K. A., Daviglus, M. L., Kesteloot, H., Ueshima, H., Zhao, L., Nicholson, J. K.*, Elliott, P*. 2008. Human Metabolic Phenotype Diversity and Its Association with Diet and Blood Pressure. Nature 453:396-U50 .
14. Holmes, E., Wilson, I. D., Nicholson, J. K.* 2008. Metabolic Phenotyping in Health and Disease. Cell 134:714-717.
15. Jia, W.*, Li, H., Zhao, L., Nicholson, J. K. 2008. Gut Microbiota: A Potential New Territory for Drug Targeting. Nature Reviews Drug Discovery 7:123-129.
16. Li, M., Wang, B., Zhang, M., Rantalainen, M., Wang, S., Zhou, H., Zhang, Y., Shen, J., Pang, X., Zhang, M., Wei, H., Chen, Y., Lu, H., Zuo, J., Su, M., Qiu, Y., Jia, W., Xiao, C., Smith, L. M., Yang, S., Holmes, E., Tang, H.*, Zhao, G.*, Nicholson, J. K.*, Li, L.*, Zhao, L.* 2008. Symbiotic Gut Microbes Modulate Human Metabolic Phenotypes. Proc. Natl. Acad. Sci. USA 105:2117-2122.
17. Nicholson, J. K.*, Lindon, J. C.* 2008. Systems Biology - Metabonomics. Nature 455:1054-1056.
18. Wang, Y., Utzinger, J., Saric, J., Li, J. V., Burckhardt, J., Dirnhofer, S., Nicholson, J. K., Singer, B. H., Brun, R., Holmes, E.* 2008. Global Metabolic Responses of Mice to Trypanosoma Brucei Brucei Infection. Proc. Natl. Acad. Sci. USA 105:6127-6132.
19. Clayton, T. A., Baker, D., Lindon, J. C., Everett, J. R., Nicholson, J. K.* 2009. Pharmacometabonomic Identification of a Significant Host-Microbiome Metabolic Interaction Affecting Human Drug Metabolism. Proc. Natl. Acad. Sci. USA 106:14728-14733.
20. Beckonert, O., Coen, M., Keun, H. C., Wang, Y., Ebbels, T. M. D., Holmes, E., Lindon, J. C., Nicholson, J. K.* 2010. High-Resolution Magic-Angle-Spinning NMR Spectroscopy for Metabolic Profiling of Intact Tissues. Nature Protocols 5:1019-1032.
21. Want, E. J.*, Wilson, I. D., Gika, H., Theodoridis, G., Plumb, R. S., Shockcor, J., Holmes, E., Nicholson, J. K. 2011. Global Metabolic Profiling Procedures for Urine Using UPLC-MS. Nature Protocols 5:1005-1018.
22. Chan, E. C. Y.*, Pasikanti, K. K., Nicholson, J. K. 2011. Global Urinary Metabolic Profiling Procedures Using Gas Chromatography-Mass Spectrometry. Nature Protocols 6:1483-1499.
23. Swann, J. R., Want, E. J., Geier, F. M., Spagou, K., Wilson, I. D., Sidaway, J. E., Nicholson, J. K.*, Holmes, E.* 2011. Systemic Gut Microbial Modulation of Bile Acid Metabolism in Host Tissue Compartments. Proc. Natl. Acad. Sci. USA 108:4523-4530.
24. Holmes, E., Kinross, J., Gibson, G. R., Burcelin, R., Jia, W., Pettersson, S., Nicholson, J. K.* 2012. Therapeutic Modulation of Microbiota-Host Metabolic Interactions. Science Translational Medicine 4:137rv6.
25. Kinross, J.*, Nicholson, J. K. 2012. Gut Microbiota Dietary and Social Modulation of Gut Microbiota in the Elderly. Nature Reviews Gastroenterology & Hepatology 9:563-564.
26. Nicholson, J. K.*, Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., Pettersson, S.* 2012. Host-Gut Microbiota Metabolic Interactions. Science 336:1262-1267.
27. Nicholson, J. K.*, Holmes, E., Kinross, J. M., Darzi, A. W., Takats, Z., Lindon, J. C. 2012. Metabolic Phenotyping in Clinical and Surgical Environments. Nature 491:384-392.
28. Balog, J., Sasi-Szabo, L., Kinross, J., Lewis, M. R., Muirhead, L. J., Veselkov, K., Mirnezami, R., Dezso, B., Damjanovich, L., Darzi, A., Nicholson, J. K.*, Takats, Z.* 2013. Intraoperative Tissue Identification Using Rapid Evaporative Ionization Mass Spectrometry. Science Translational Medicine 5:194ra93.
29. Smith, M. I., Yatsunenko, T., Manary, M. J., Trehan, I., Mkakosya, R., Cheng, J., Kau, A. L., Rich, S. S., Concannon, P., Mychaleckyj, J. C., Liu, J., Houpt, E., Li, J. V., Holmes, E., Nicholson, J., Knights, D., Ursell, L. K., Knight, R., Gordon, J. I.* 2013. Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor. Science 339:548-554 .
30. Swann, J. R., Spagou, K., Lewis, M., Nicholson, J. K., Glei, D. A., Seeman, T. E., Coe, C. L., Goldman, N., Ryff, C. D., Weinstein, M., Holmes, E.* 2013. Microbial-Mammalian Cometabolites Dominate the Age-Associated Urinary Metabolic Phenotype in Taiwanese and American Populations. Journal of Proteome Research 12:3166-3180 .
31. Zheng, X., Zhao, A.*, Xie, G., Chi, Y., Zhao, L., Li, H., Wang, C., Bao, Y., Jia, W., Luther, M., Su, M., Nicholson, J. K., Jia, W.* 2013. Melamine-Induced Renal Toxicity Is Mediated by the Gut Microbiota. 2013. Science Translational Medicine 5:172ra22.
32. Veselkov, K. A.*, Mirnezami, R., Strittmatter, N., Goldin, R. D., Kinross, J., Speller, A. V. M., Abramov, T., Jones, E. A., Darzi, A., Holmes, E., Nicholson, J. K., Takats, Z. 2014. Chemo-Informatic Strategy for Imaging Mass Spectrometry-Based Hyperspectral Profiling of Lipid Signatures in Colorectal Cancer. Proc. Natl. Acad. Sci. USA 111:1216-1221.
33. Elliott, P.*, Posma, J. M., Chan, Q., Garcia-Perez, I., Wijeyesekera, A., Bictash, M., Ebbels, T. M. D., Ueshima, H., Zhao, L., van Horn, L., Daviglus, M., Stamler, J., Holmes, E., Nicholson, J. K.* 2015. Urinary Metabolic Signatures of Human Adiposity. Science Translational Medicine 7:285ra62.
34. O'Keefe, S. J. D.*, Li, J. V., Lahti, L., Ou, J., Carbonero, F., Mohammed, K., Posma, J. M., Kinross, J., Wahl, E., Ruder, E., Vipperla, K., Naidoo, V., Mtshali, L., Tims, S., Puylaert, P. G. B., DeLany, J., Krasinskas, A., Benefiel, A. C., Kaseb, H. O., Newton, K., Nicholson, J. K., de Vos, W. M., Gaskins, H. R., Zoetendal, Fat, E. G. 2015. Fat, Fibre and Cancer Risk in African Americans and Rural Africans. Nature Communications 6:6342.