諾貝爾化學獎得主
耶魯大學教授
霍華德·休斯醫學研究所研究員
狗万外围充值 名譽教授
托馬斯·施泰茨 (Thomas A. Steitz)1940年出生於美國威斯康星州的密爾沃基，1962年本科畢業於勞倫斯大學化學係。1966年獲得哈佛大學分子生物學和生物化學博士學位，1967年-1970年在劍橋大學MRC分子生物學實驗室作博士後。1970年加入耶魯大學至今，現為耶魯大學分子生物物理學和生物化學係的斯特林教授，以及霍華德·休斯醫學研究所的研究員。2009年，因對核糖體結構和功能的研究而與文卡特拉曼·拉馬克裏希南和阿達·約納特共同獲得2009年諾貝爾化學獎。
Dr. Steitz was born in Milwaukee, Wisconsin in 1940. He received a B.A. degree in chemistry in 1962 from Lawrence College in Appleton, Wisconsin, and a Ph.D. degree in molecular biology and biochemistry in 1966 from Harvard, with William Lipscomb. He did the postdoctoral research as a Jane Coffin Childs Postdoctoral Fellow at the MRC Laboratory of Molecular Biology at the University of Cambridge during 1967–1970. Dr. Steitz joined the Yale faculty in 1970, where he has remained. In 2009, he was awarded the Nobel Prize in Chemistry along with Venkatraman Ramakrishnan and Ada Yonath "for studies of the structure and function of the ribosome".
使用結構生物學和生物化學研究參與分子生物學中心法則過程（DNA複製、轉錄和翻譯）的蛋白質核酸複合物機器的結構和工作機理。
Using structural biology and biochemistry to determine the detailed molecular mechanisms by which the proteins and nucleic acids involved in the central dogma of molecular biology (DNA replication, transcription, and translation) achieve their biological functions.
- Foreign Member, the Royal Society (2011)
- Nobel Prize in Chemistry (2009)
- Gairdner International Award (2007)
- Keio Medical Science Prize (2006)
- AAAS Newcomb Cleveland Prize (2001)
- Rosenstiel Award for Distinguished Work in Basic Medical Research (2001)
- Member, National Academy of Sciences (1990)
- Pfizer Award in Enzyme Chemistry (1980)
1. Gagnon, M. G., Lin, J. & Steitz, T. A. (2016). Elongation factor 4 remodels the A-site tRNA on the ribosome. PNAS 113, 4994–4999
2. Lin, J., Gagnon, M.G., Bulkley, D., Steitz, T.A. (2015). Conformational changes of elongation factor G on the ribosome during tRNA translocation. Cell 160, 219-227.
3. Gagnon, M.G., Lin, J., Bulkley, D., Steitz, T.A. (2014). Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome. Science 345, 684-687.
4. Lomakin, I., Steitz, T.A. (2013). The initiation of mammalian protein synthesis and mRNA scanning mechanism. Nature 500, 307-311.
5. Zuo, Y., Wang, Y., Steitz, T.A. (2013). The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex. Mol Cell 50(3), 430-436.
6. Polikanov, Y.I., Blaha, G.M. Steitz, T.A. (2012). How Hibernation Factors RMF, HPF, and YfiA Turn Off Protein Synthesis. Science 336, 915-918.
7. Itsathitphaisarn, O., Wing, R.A., Eliason, W.K., Wang, J., Steitz, T.A. (2012). The Hexameric Helicase DnaB Adopts a Nonplanar Conformation during Translocation. Cell 151, 267-277.
8. Gagnon, M.G., Seetharaman, S.V., Bulkley, D., Steitz, T.A. (2012). Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome. Science 335, 1370-1372.