王陳繼

發布者：王詩銘發布時間：2021-12-10瀏覽次數：10

教師基本信息

職稱：副研究員

電子郵箱：chenjiwang@fudan.edu.cn

辦公地點：万博英超狼队网官方网 C515室

辦公電話：021-31246559


個人簡介  

男，1981年出生，博士，副研究員，博士生導師。2004年畢業於四川大學理科創新班，獲理學學士學位；2010年畢業於万博英超狼队网官方网 ，獲理學博士學位；2010年7月至2016年6月任万博英超狼队网官方网 科研助理（助理研究員）；2016年7月至2017年11月任万博英超狼队网官方网 青年副研究員，2017年12月任万博英超狼队网官方网 副研究員。


研究方向

1. 研究惡性腫瘤高頻突變基因（特別是泛素-蛋白酶體途徑相關基因）在腫瘤中的作用機製，闡明其致癌機理，並探索其成為腫瘤 “精準治療”分型依據和藥物靶標的可能性；

2. 研究泛素-蛋白酶體、自噬體、溶酶體、線粒體和囊泡運輸等相關途徑基因突變導致人類神經/代謝性遺傳病、神經退行性疾病的分子機製及靶向治療的策略。


獲獎情況

遺傳與發育協同創新中心2018年度“十大科技進展”

2018年 狗万外围充值 泓翼獎教金   

2017年 生科院院長獎

2016、2019年 複星醫藥獎教金  


代表性論文和論著

  1. Shi Q, Jin X, Zhang P, Li Q, He H, Zhao X, Lv Z, Zhao S, Li Y, Gao K§, Wang C§. SPOP Mutations Promote p62/SQSTM1-dependent Autophagy and Nrf2 Activation in Prostate Cancer. Cell Death Differ. 2021. doi : 10.1038/s41418-021-00913-w.

  2. Zhang P§, Gao K§, Zhang L, Sun H, Zhao X, Liu Y, Lv Z, Shi Q, Chen Y, Jiao D, Li Y, Gu W§, Wang C§. CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14ARF degradation. Cell Death Differ. 2021 Nov 6. doi: 10.1038/s41418-021-00890-0.

  3. Zhang J, Zhang L, Nie J, Lin Y, Li Y, Xu W, Zhao J, Zhao SM§, Wang C§. Calcineurin Inactivation Inhibits Pyruvate Dehydrogenase Complex Activity and Induces the Warburg Effect. Oncogene. 2021 Oct 19. doi: 10.1038/s41388-021-02065-0.

  4. Zhang J, Kun Gao K, Xie H, Wang D, Zhang P, Wei T, Yan Y, Pan Y, Chen H, Shi Q, Yao Li Y, Zhao S, Hou X, Weroha SJ, Wang Y, Zhang J, Karnes RJ, Wang L, Wang C§, Huang H§. SPOP mutation induces DNA methylation via stabilizing GLP/G9a. Nat Comm. 2021 Sep 29;12(1):5716.

  5. Ma J, Shi Q, Cui G, Sheng H, Botuyan MV, Zhou Y, Yan Y, He Y, Wang L, Wang Y, Georges Mer§, Ye D§, Wang C§, Huang H§. SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition. Nat Comm. 2021 Oct 1;12(1):5779.

  6. Jin X§, Qing S, Li Q, Zhuang H, Shen L, Li J, Qi H, Lin T, Lin Z, Wang J, Cao X, Yang J, Ma Q, Cong L, Xi Y, Fang S, Meng X, Gong Z, Ye M, Wang S§, Wang C§, Gao K§. Prostate cancer-associated SPOP mutations lead to genomic instability through disruption of the SPOP-HIPK2 axis. Nucleic Acids Res. 2021 Jul 9;49(12):6788-6803.

  7. Zhang L, Zhang J, Liu Y, Zhang P, Nie J, Zhao R, Shi Q, Sun H, Jiao D, Chen Y, Zhao X, Huang Y, Li Y, Zhao JY, Xu W, Zhao SM§, Wang C§. Mitochondrial STAT5A promotes metabolic remodeling and the Warburg effect by inactivating the pyruvate dehydrogenase complex. Cell Death Dis. 2021 Jun 19;12(7):634.

  8. Jin X, Shi Q, Li Q, Zhou L, Wang J, Jiang L, Zhao X, Feng K, Lin T, Lin Z, Zhuang H, Yang J, Hu C, Zhang L, Shen L, Lu Y, Zhu J, Wang H, Qi H, Meng X, Xi Y, Pan J, Fang S, Tian H, Zhou C, Zhang P, Gao K, Zhao S, Li Y, Gong Z, Wang C§. CRL3-SPOP Ubiquitin Ligase Complex Suppresses the Growth of Diffuse Large B-cell Lymphoma by Negatively Regulating the MyD88/NF-κB Signaling. Leukemia. 2020 May;34(5):1305-1314.

  9. Shi Q, Zhu Y, Ma J, Chang K, Ding D, Bai Y, Gao K, Zhang P, Mo R, Feng K, Zhao X, Zhang L, Sun H, Jiao D, Chen Y, Sun Y, Zhao S, Huang H, Li Y§, Ren S§, Wang C§. Prostate Cancer-associated SPOP Mutations Enhance Cancer Cell Survival and Docetaxel Resistance by Upregulating Caprin1-dependent Stress Granule Assembly. Mol Cancer. 2019 Nov 26;18(1):170.

  10. Gao K§, Zhang Y, Shi Q, Zhang J, Zhang L, Sun H, Jiao D, Zhao X, Tao H, Wei Y, Wang Y, Saiyin H, Zhao S, Li Y, Zhang P§, Wang C§. iASPP–PP1 complex is required for cytokinetic abscission by controlling CEP55 dephosphorylation. Cell Death Dis. 2018 May 1;9(5):528.

  11. Zhang P, Wang D, Ren S, Zhao Y, Gao K, Ye Z, Wang S, Lin D, Pang X, Pan C, Zhu Y, Yan Y, Wu D, He Y, Zhang J, Lu D, Liu X, Yu L, Zhao S, Li Y, Wang L, Wang Y, Chen Y, Sun Y§, Wang C§, Huang H§. Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation. Nat Med. 2017 Sep;23(9):1055-1062.

  12. Zhang Y, Wang Y, Wei Y, Wu J, Zhang P, Shen S, Saiyin H, Wumaier R, Wang C§, Yu L§. Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells. Cancer Lett. 2016 Mar 1;372(1):101-9.

  13. Peng J, Ma J, Li G, Zhang P, Gao K, Jin X, Wang C§, Fan J§. Stabilization of MCRS1 by BAP1 prevents chromosome instability in renal cell carcinoma. Cancer Lett. 2015 Dec 1;369(1):167-74.

  14. Zhang P, Gao K, Jin X, Ma J, Peng J, Tang Y, Zhang Y, An J, Yan J, Dong Y, Huang H, Yu L§,Wang C§. Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α (ERα) protein turnover. Cell Death Dis.2015 Mar 12;6:e1687.

  15. Gao K, Tang W, Wang D, Zhang P, Yu L, Wang C§, Wu D§. Front Signal-Dependent Accumulation of RHOA Inhibitor FAM65B at Leading Edges Polarizes Neutrophils.J Cell Sci.2015 Mar 1;128(5):992-1000.

  16. Zhang P, Gao K, Tang Y, Jin X, An J, Yu H, Wang H, Zhang Y, Wang D, Huang H, Yu L§, Wang C§. Destruction of DDIT3/CHOP protein by wild-type SPOP but not prostate cancer-associated mutants. Hum Mutat. 2014 Sep;35(9):1142-51.

  17. An J*, Wang C*, Deng Y, Yu L, Huang H. Destruction of full-length androgen receptor by wild-type SPOP, but not prostate-cancer-associated mutants. Cell Rep. 2014 Feb 27;6(4):657-69.

  18. Xiao Q*, Qu K*, Wang C*, Kong Y, Liu C, Jiang D, Saiyin H, Jia F, Ni C, Chen T, Zhang Y, Zhang P, Qin W, Sun Q, Wang H, Yi Q, Liu J, Huang H, Yu L. HDGF-related protein-3 is required for anchorage-independent survival and chemoresistance in hepatocellular carcinomas. Gut. 2013 Mar;62(3):440-51.

  19. Yang Y*,Wang C*, Zhang P*, Gao K, Wang D, Yu H, Zhang T, Jiang S, Hexige S, Hong Z, Yasui A, Liu JO, Huang H, Yu L. Polycomb group protein PHF1 regulates p53-dependent cell growth arrest and apoptosis. J Biol Chem. 2013 Jan 4;288(1):529-39.

  20. Wang C*, An J*, Zhang P, Xu C, Gao K, Wu D, Wang D, Yu H, Liu JO, Yu L. The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation. Biochem J. 2012 Jun; 1;444(2):279-89.

  21. Zhang P*,Wang C*, Gao K, Wang D, Mao J, An J, Xu C, Wu D, Yu H, Liu JO, Yu L. The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation. J Biol Chem. 2010 Mar 19; 285(12):8869-79.


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