教師基本信息
職稱：教授
電子郵箱：bkkuai@fudan.edu.cn
辦公地點：万博英超狼队网官方网 D413室
辦公電話：021-31246639
個人簡介
万博英超狼队网官方网 教授、生物化學與分子生物學專業博士生導師。英國威爾士大學生物工程學博士，英國草地環境研究所（BBSRC-IGER）博士後，美國杜克大學（Duke）訪問教授。中國植物生理與分子生物學學會成熟與衰老專業委員會主任委員，上海市植物生理與分子生物學學會副理事長，上海市農業工程學會副理事長。
本人領導的實驗室在國際上率先克隆了綠色器官衰老進程中葉綠素降解的第一個關鍵酶基因NYEs/SGRs（孟德爾豌豆和大豆綠粒性狀的調控因子）和第二個關鍵酶基因CRN1/PPH。揭示了主要植物激素、光信號和甲基化調控葉綠素降解和葉片衰老的多個關鍵調控路徑。
研究方向
1）蔬果成熟過程中營養成分/風味物質形成的調控機理
主要探索番茄、水果玉米等生食蔬果成熟過程中營養成分/風味物質形成的協同調控機理。生食蔬果是健康營養物質的主要來源之一，長期以提高產量與效益為主的品種改良使得其營養品質和風味口感大大降低。我們以遺傳學、分子生物學和代謝組學等手段研究其營養成分/風味物質形成的遺傳基礎和分子機理，並探索其改良路徑。
2）綠色器官成熟衰老進程中葉綠素降解的調控機理
重點研究主要植物激素、環境因子和表觀遺傳調控綠色器官成熟衰老進程中葉綠素降解的特異性機理及其關聯調控關係。我們借助於擬南芥模式體係，利用分子生物學、基因組學和生物信息學等技術手段，係統研究了綠色器官衰老的關鍵生化事件---葉綠素降解啟動的信號與關鍵調控節點，並解析了與葉片衰老進程關聯調控的網絡關係。
3）葉片衰老與抗逆性之間的協同調控機理
試圖闡釋葉片衰老與抗旱性/抗病性之間的協同調控關係。植物的自養屬性和固著生活方式決定了其葉片在營養運籌方麵的雙重功能：發育成熟的葉片主營光合同化功能，而在遭遇逆境脅迫啟動衰老時葉片則營營養物質的再動員功能。葉片衰老的適時啟動，使得其同化能力和營養物質再動員能力雙雙達到最大化，不僅能夠保障植株生長發育的競爭優勢，也能夠有助於作物產量和品質的提高。
獲獎情況
1）主持培育出了衰老葉片
黃化和抵抗鏽病的草坪草新品種“滯綠1號”，獲得上海市優秀發明選拔賽一等獎（2004年）
2）曾獲上海市優秀青年教師和曙光學者稱號
3)曾被委任為上海市科委重大攻關研究計劃《重要轉基因作物安全性研究》首席專家
代表性論文和論著
1. Wang X, Gao J, Gao S, Song Y, Yang Z, Kuai B* (2019) The H3K27me3 demethylase REF6 promotes leaf senescence through directly activating major senescence regulatory and functional genes in Arabidopsis. PLoS Genet. 15(4): e1008068. https:// i.org/10.1371/journal.pgen.1008068
2.Xie Z, Wu S, Chen J, Zhu X, Zhou X, Hörtensteiner S, Ren G*, KuaiB* (2019) The C-terminal cysteine-rich motif of NYE1/SGR1 is indispensable for its function in chlorophyll degradation in Arabidopsis. Plant Mol.Biol. https://doi.org/10.1007/s11103-019-00902-1
3. Li Z, Wu S, Chen J, Wang X, Gao J, Ren G*, KuaiB* (2017) NYEs/SGRs-mediated chlorophyll degradation is critical for detoxification during seed maturation in Arabidopsis. Plant J. 92:650-661
4. Chen J, Zhu X, Ren J, Qiu K, Li Z, Xie Z, Gao J, Zhou X*, Kuai B* (2017) Suppressor of Overexpression of CO 1 negatively regulates dark-induced leaf degreening and senescence by directly repressing pheophytinase and other senescence-associated genes in Arabidopsis. Plant Physiol. 173(3):1881-1891
5. Gao S, Gao J, Zhu X, Song Y, Li Z, Ren G, Zhou X*, Kuai B* (2016) ABF2, ABF3, and ABF4 promote ABA-mediated chlorophyll degradation and leaf senescence by transcriptional activation of chlorophyll catabolic genes and senescence-associated genes in Arabidopsis. Mol. Plant 9(9):1272-1285
6. Wu S, Li Z, Yang L, Xie Z, Chen J, Zhang W, Liu T, Gao S, Gao J, Zhu Y, Xin J, Ren G*, Kuai B* (2016) NON-YELLOWING2 (NYE2), a close paralog of NYE1, plays a positive role in chlorophyll degradation in Arabidopsis. Mol. Plant 9(4):624-627
7. Li Z, Wang X, Chen J, Gao J, Zhou X*, Kuai B* (2016) CCX1, a putative cation / Ca2+ exchanger, participates in the regulation of reactive oxygen species homeostasis and leaf senescence. Plant and Cell Physiol. 57 (12):2611-2619
8. Li S, Gao J, Yao L, Ren G, Zhu X, Gao S, Qiu K, Zhou X*, Kuai B* (2016) The role of ANAC072 in the regulation of chlorophyll degradation during age- and dark-induced leaf senescence. Plant Cell Rep. 35 (8):1729-1741
9. Zhu X, Chen J, Xie Z, Gao J, Ren G, Gao S, Zhou X*, Kuai B* (2015) Jasmonic acid promotes degreening via MYC2/3/4- and ANAC019/055/072-mediated regulation of major chlorophyll catabolic genes. Plant J. 84:597-610
10. Qiu K, Li Z, Yang Z, Chen J, Wu S, Zhu X, Gao S, Gao J, Ren G, Kuai B*, Zhou X* (2015) EIN3 and ORE1 accelerate degreening during ethylene-mediated leaf senescence by directly activating chlorophyll catabolic genes in Arabidopsis. PLoS Genet. 11(7): e1005399 doi:10.1371/journal.pgen.1005399
11. Wang X, Gao J, Zhu Z, Dong X, Wang X, Ren G, Zhou X*, Kuai B*（2015） TCP transcription factors are critical for the coordinated regulation of ISOCHORISMATE SYNTHASE 1 expression in Arabidopsis thaliana. PlantJ. 82:151-162
12. Song Y, Yang C, Gao S, Zhang W, Li L*, Kuai B*(2014) Age-Triggered and Dark-Induced leaf senescence require the bHLH transcription factors PIF3, 4 and 5. Mol. Plant 7:1776-1787
13. Ren G, Zhou Q, Wu S, Zhang Y, Zhang L, Huang J, Sun Z, Kuai B*（2010）Reverse genetic identification of CRN1 and its distinctive role in chlorophyll degradation in Arabidopsis. J. Integr. Plant Biol. 52 (5):496-504
14. Ren G, An K, Liao Y, Zhou X, Cao Y, Zhao H, Ge X, Kuai B*（2007） Identification of a novel chloroplast protein AtNYE1 regulating chlorophyll degradation during leaf senescence in Arabidopsis. Plant Physiol. 144:1429-1441
綜述與評述
1. Kuai B, Chen J, Hörtensteiner S* (2018) The biochemistry and molecular biology
of chlorophyll breakdown, J EXP BOT. 69(4):751-767
2. Zhu X, Chen J, Qiu K, Kuai B* (2017) Phytohormone and light regulation of chlorophyll degradation. Front Plant Sci, doi: 10.3389/fpls.2017.01911
3.Chen J, Ren G, Kuai B* (2016) The Mystery of Mendel's stay-green: magnesium stays chelated in chlorophylls. Mol. Plant 9(12):1556-1558