趙健元

發布者：王詩銘發布時間：2021-06-28瀏覽次數：553

教師基本信息

姓名：趙健元

職稱：研究員

職務：無

電子郵箱：zhaojy@fudan.edu.cn

辦公地點：C111

辦公電話：021-31246782

個人網頁/課題組主頁：


研究方向

1、代謝失調的致病機製；2、代謝物的感知及信號轉導


個人簡介

趙健元，男，万博英超狼队网官方网 研究員，博士生導師，國家基金委優秀青年基金（2017年）和863青年科學家項目（2015年）獲得者。2011年博士畢業於狗万外围充值 ，之後赴美國約翰霍普金斯大學醫學院從事博士後工作，2013年人才引進回狗万外围充值 生科院。致力於代謝物信號失調致發育相關疾病的分子機製研究，在出生缺陷、腫瘤等疾病的發病機製研究中取得係列高水平研究成果。以通訊及第一作者（含共同）發表研究論文二十餘篇。近五年獲批十餘項省部級項目，作為主要完成人獲教育部自然科學一等獎和國家婦幼健康科學技術一等獎。


招生專業

遺傳學


代表性論文和論著

（*第一作者，#通訊作者，IF：5-year impact）

  1. Wang XH*, Xu S*, Zhou XY*, … Jin LP#, Zhao JY#.Low embryonic villous succinate accumulation increases recurrent spontaneous abortion risk. Nature Communications. 2021. In press. (IF: 13.6)

  2. Xu S*, Tao H*, Cao W*, … Zhao JY#. Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis.Signal Transduction and Targeted Therapy. 2020. In press. (IF: 13.2)

  3. Zhang Y*, … Zhao JY#, Zhou XY#. Two sides of NNMT in alcoholic and nonalcoholic fatty liver development. Journal of Hepatology. 2020. doi: 10.1016/j.jhep.2020.11.049. (IF: 20.6)

  4. Qu YY*, Zhao R*, Zhang HL*, … Ye DW#, Zhao SM#, Zhao JY#. Inactivation of the AMPK-GATA3-ECHS1 Pathway Induces Fatty Acid Synthesis That Promotes Clear Cell Renal Cell Carcinoma Growth.Cancer Research. 2020 Jan 15; 80(2):319-333. (IF: 9.9)

  5. Mei X*, Qi D*, Zhang T*, Zhao Y*, … Wang H#, Zhao JY#, Zhao S#, Xu W#. Inhibiting MARSs reduces hyperhomocysteinemia-associated neural tube and congenital heart defects. EMBO Molecular Medicine. 2020 Mar 6; 12(3):e9469. (IF: 10.4)

  6. Li Y*, Yao CF*, … Zhao SM#, Zhao JY#. APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression. Nature Communications. 2019 Jun 7; 10(1):2502. doi: 10.1038/s41467-019-10375-x.2. (IF: 13.6)

  7. Wang D*, Zhao R*, Qu YY*, Mei XY*, … Zhao SM#, Zhao JY#. Colonic lysine homocysteinylation induced by high-fat diet suppresses DNA damage repair. Cell Reports. 2018 Oct 9; 25:398-412. (IF: 8.8)

  8. Wang D*, Wang F*, Shi KH*, … Zhao SM#, Wang H#, Zhao JY#. Lower circulating folate induced by a Fidgetin intronic variant is associated with reduced congenital heart disease Susceptibility. Circulation. 2017 May 2; 135(18):1733-1748. (IF: 21.1)

  9. Xu S*, Liu CX*, … Zhao JY#, Zhao SM#. Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation. Signal Transduction and Targeted Therapy. 2017 Feb 10; 2, e16035. doi: 10.1038/sigtrans.2016.35. (IF: 13.2)

  10. Zhao JY*, Liang L*, Gu X*, …Tao YX#. DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons. Nature Communications. 2017 Mar 8; 8:14712. doi: 10.1038/ncomms14712. (IF: 13.6)

  11. Xu JT*, Zhao JY*, Zhao X*, … Tao YX#. Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia. Journal of Clinical Investigation. 2014 Feb; 124(2):592-603. (IF: 13.4)

  12. Zhao JY*, Qiao B*, Duan WY*, … Huang GY#, Jin L#, Wang HY#. Genetic variants reducing MTR gene expression increase the risk of congenital heart disease in Han Chinese populations. European Heart Journal. 2014 Mar; 35(11):733-42. (IF: 22.2)

  13. Zhao JY*, Yang XY*, Shi KH*, … Wang HY#. A functional variant in the cystathionine β-synthase gene promoter significantly reduces congenital heart disease susceptibility in a Han Chinese population. Cell Research. 2013, 23:242-253. (IF: 20.4)

  14. Zhao X*, Tang Z*, Zhang H*, Atianjoh FE*, Zhao JY*, … Tao YX#. A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons. Nature Neuroscience. 2013 Aug; 16(8):1024-31. (IF: 21.5)

  15. Zhao JY*, Yang XY*, Gong XH*, … Qiao B#, Wang HY#. Functional variant in methionine synthase reductase intron-1 significantly increases the risk of congenital heart disease in the Han Chinese population. Circulation. 2012 Jan 24; 125(3):482-90. (IF: 21.1)

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