教師基本信息
姓名：餘巍
職稱：研究員
職務：無
電子郵箱：yuw@fudan.edu.cn
辦公地點：D303
辦公電話：021-31246672
個人網頁/課題組主頁：
研究方向
代謝調控衰老
個人簡介
1978年生，湖北鄂州人。2009年博士畢業於狗万外围充值 。 2009年至2014年，於美國威斯康辛大學麥迪遜分校做博士後和助理研究員。2014年被万博英超狼队网官方网 聘為研究員、博士生導師，入選上海市“東方學者”特聘教授和“國家海外高層次人才引進計劃”人才項目。係統揭示去酰化修飾酶家族是調控衰老代謝疾病的一條重要的通路，以第一或通訊作者（含並列）發表論文十餘篇，包括Cell、Molecular Cell、Nature Communications、 PNAS、Cell Reports、JBC等，SCI他引超過1700 次，其中2010年Cell文章是ESI高被引論文，研究成果獲得國際同行高度評價。現任中國細胞生物學會衰老細胞生物學分會委員，中國老年學和老年醫學學會抗衰老分會委員，上海市生化與分子生物學協會理事。
授課情況
AIBS(中)，發育與代謝，微生物學前沿
招生專業
細胞生物學、微生物學
代表性論文和論著
Wang C, Wan X, Yu T, Huang Z, Shen C, Qi Q, Xiang S, Chen X, Arbely E, Ling ZQ, Liu CY*, Yu W*. Acetylation Stabilizes Phosphoglycerate Dehydrogenase by Disrupting the Interaction of E3 Ligase RNF5 to Promote Breast Tumorigenesis. Cell Reports 2020, 32 (6), 108021. (*corresponding author)
Wan X, Wang C, Huang Z, Zhou D, Xiang S, Qi Q, Chen X, Arbely E, Liu CY, Du P*, Yu W*. Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell. Cell Death & Disease 2020, 11: 649 . (*corresponding author)
Zhu Z#, Song J#, Guo Y#, Huang Z, Chen X, Dang X, Huang Y, Wang Y, Ou W, Yang Y, Yu W*, Liu CY*, Cui L*. LAMB3 promotes tumour progression through the AKT–FOXO3/4 axis and is transcriptionally regulated by the BRD2/acetylated ELK4 complex in colorectal cancer. Oncogene 2020 29,4666-4680 (*corresponding author)
Song J#, Chen W#, Cui X#, Huang Z, Wen D, Yang Y, Yu W*, Cui L*, Liu CY*. CCBE1 promotes tumor lymphangiogenesis and is negatively regulated by TGFβ signaling in colorectal cancer. Theranostics 2020 10(5), 2327-2341 (*corresponding author)
Wei Z#, Song J#, Wang G, Cui X, Zheng J, Tang Y, Chen X, Li J, Cui L*, Liu CY*, Yu W*. Deacetylation of Serine Hydroxymethyl-transferase 2 by SIRT3 promotes Colorectal Carcinogenesis. Nature Communications 2018 9 (1), 4468 (*corresponding author)
Cao X#, Li C#, Xiao S#, Tang Y, Huang J, Zhao S, Li X, Li J, Zhang R, and Yu W*. Acetylation promotes TyrRS nuclear translocation to prevent oxidative damage. PNAS 2017 114 (4): 687-692 (*corresponding author)Yu W#, Denu RA#, Krautkramer KA, Grindle KM, Yang DT, Asimakopoulos F, Hematti P, Denu JM*. Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies. J. Bio. Chem. 2016 Feb 12; 291(7): 3268-79 (# equal contribution)
Yu W, Dittenhafer-Reed KE, Denu JM*. SIRT3 deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status. J. Bio. Chem. 2012 Apr 20; 287 (17), 14078-14086. (Best of 2012 paper)
Hallows WC#, Yu W#, Smith BC, Devries MK, Ellinger JJ, Someya S, Shortreed MR, Prolla T, Markley JL, Smith LM, Zhao S, Guan KL, Denu JM*. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Molecular Cell 2011 Jan 21; 41(2):139-49. (# equal contribution)
Someya S#, Yu W#, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, Tanokura M, Denu JM*, Prolla TA*. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 2010 Nov 24; 143(5):802-12. (# equal contribution)
Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Yang P, Li H, Li Y, Shi J, Qin l, Lei Q, Xiong Y, Guan KL. Regulation of cellular metabolism by protein lysine acetylation. Science 2010 327.5968,1000-1004.
Yu W, Lin Y, Yao J, Huang W, Lei Q, Xiong Y, Zhao S, Guan KL. Lysine 88 Acetylation Negatively Regulates Ornithine Carbamoyltransferase Activity in Response to Nutrient Signals. J. Bio. Chem. 2009 284(20): 13669-1367